Its history is not known precisely. From a tombstone it seems that the building dates back to the time of Constantine I, the mid-fourth century, and it is built on the ruins of a Roman villa of the first century BC, to commemorate the work performed on the Via Tiburtina. There is no foundation to the medieval hypothesis that it was a temple dedicated to the personification of cough, to ward off the disease from the Tiburtina population. The building became a church dedicated to the Virgin Mary in the tenth century using material from the nearby sanctuary of Hercules. Inside it has a few late medieval frescoes. It was abandoned between the XVII and XVIII centuries and is privately owned.